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KMID : 0928320150150040202
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Korean Journal of Health Promotion and Disease Prevention
2015 Volume.15 No. 4 p.202 ~ p.208
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Association between Insulin Resistance and Benign Prostatic Hyperplasia in Healthy Middle-aged Korean Men
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손희승:Son Hee-Seung
서병성:Suh Byung-Seong/김수근:Kim Soo-Geun/명준표:Myeon Jun-Pyo/손유일:Shon You-Il/김희윤:Kim Hee-Yun/정한슬:Jeong Han-Seur
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Abstract
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Background: We examined the association between insulin resistance assessed by homeostatic model assessment- insulin resistance (HOMA-IR) and benign prostatic hyperplasia (BPH) in healthy middle-aged male subjects.
Methods: A cross-sectional study included 1,727 male subjects, aged 40-59 year, free of medication history for BPH who received a transrectal ultrasonography and completed a structured questionnaire in 2011. Multiple logistic regression analysis was performed to evaluate the relationships of HOMA-IR with BPH across the tertile of HOMA-IR.
Results: The prevalence of BPH was 24.4% (421 out of 1,727). It was increased across HOMA-IR tertiles in crude and age-adjusted models. In a multivariable-adjusted model after adjusting potential confounders such as age, body mass index (BMI), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alcohol consumption, smoking, exercise and meat consumption, odds ratios (95% confidence intervals, CIs) of BPH for 2nd tertile and 3rd tertile compared to 1st tertile were 1.76 (1.31-2.35), and 1.83 (1.34-2.48), respectively.
Conclusions: In middle-aged, healthy men, higher HOMA-IR was significantly associated with higher prevalence of BPH, supporting insulin resistance as an independent risk factor for BPH.
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KEYWORD
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Insulin resistance, Benign prostatic hyperplasia, Middle-aged
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